Dr. Kahleova has conducted several clinical trials, using a plant-based diet in the treatment of obesity, diabetes, and metabolic disease. Her research showed that a plant-based diet leads to a greater weight loss and improvement in metabolism, and addresses multiple mechanisms behind diabetes. Her research proved that eating a large breakfast and lunch is more beneficial than eating six smaller meals a day for patients with type 2 diabetes. Her research on meal frequency and timing showed that eating less frequently, no snacking, consuming breakfast, and eating the largest meal in the morning may be effective methods for preventing long-term weight gain. As a member of the American Diabetes Association and as a board member of the Diabetes and Nutrition Study Group of the European Association for the Study of Diabetes, Dr. Kahleova is directly involved in the process of updating the nutritional recommendations for patients with diabetes.